Phone: (+65) 6790 4613
Eligible for 1 PhD scholarship supported by school in AY2020
Current Research Interests
My research is focused on the development of nanomedicines to treat inflammatory diseases (cardiovascular and neurological disease principally), with large emphasis on in vivo pre-clinical studies. In collaborations with clinicians from different hospitals or institutes in Singapore, my research is highly translational, and is broadly applicable to many pathological conditions. The goal is to choose nanomaterials in relation to the drug and the disease and develop nanomedicines with high efficacy and safety profiles.
Dr Bertrand CZARNY joined the French governmental agency CEA (Atomic Energy Commission) in 2001. For more than 10 years, he was responsible, as a Team Leader, for the biodistribution, drug delivery and toxicology studies of nanoparticles. During this period, he received his Ph.D. degree on structural and functional engineering of biomolecules from the University of Paris Descartes, Pharmacy Paris V (France). As a postdoctoral researcher at Utrecht University (UU) Netherlands (2014-2016), in Professor Gert Storm’s laboratory, Dr Czarny developed preclinical studies on different inflammatory diseases using nanoparticles drug formulations. During this period, in view of his expertise in animal models, Dr Czarny was offered a Visiting Senior scientist position at the National University of Singapore (NUS) in 2016 and then joined the Nanyang Technical University (NTU) in the School of Material Sciences and Engineering (MSE) and the Lee Kong Chian School of Medicine (LKC) as Principal Research Fellow (2017). Since 2018, he has started his independent research group as an Assistant Professor at NTU.
Goh WJ, Ong WY, Torta F, Schiffelers RM, Storm G, Czarny B*, Giorgia Pastorin*. Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: A Cost-Effective Alternative, Scientific Reports, 2017.
Goh WJ, Zou S, Lee CK, Wang JW, Czarny B, Giorgia Pastorin. EXOPLEXs: Chimeric Drug Delivery Platform from the fusion of Cell Derived Nanovesicles and Liposomes. Biomacromolecules, 2017
Allijn IE*, Czarny BM*, Wang X, Chong SY, Weiler M, da Silva AE, Metselaar JM, Lam CS, Pastorin G, de Kleijn DP, Storm G, Wang JW, Schiffelers RM. Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction. J Control Release, 2017
Goh WJ, Lee CK, Zou S, Woon E, Czarny B, Giorgia Pastorin. Doxorubicin loaded Cell Derived Nanovesicles: An Alternative Targeted Approach for Anti-Tumor Therapy, International Journal of Nanomedicine, 2017.
Czarny B, Georgin D, Berthon F, Plastow G, Pinault M, Patriarche G, Thuleau A, Mayne-L'Hermite M, Taran F and Dive V, Carbon nanotube translocation to distant organs after pulmonary exposition: insights from in situ 14C radiolabelling and tissue radioimaging. ACS Nano, 2014.