Current Research Interests
Dr Agrawal is the clinician scientist, currently engaged in development of sustained release platform for anti vascular endothelial growth factors for age related macular degeneration and diabetic retinopathy in collaboration with Prof Subbu and team at School of MSE, NTU. He is also looking at novel peptides for its anti angiogenesis properties and its potential application for neovascular diseases related to the back of the eye. He is also engaged in the collaborative grant with IMCB, A*Star on cytokines and biological markers for ocular inflammation and age related macular degeneration and polypoidal choroidal vasculopathy. He is actively pursuing microfluidics in collaboration with NUS, Singapore to look at rheological characteristics of the blood in retinal vascular disorders. His clinical research interest spans across ocular trauma and ocular inflammation and he is currently leading an international study on ocular tuberculosis and its management with anti tubercular therapy. Through his work on choroidal imaging, he has proposed choroidal vascularity index as a potential optical biomarker in ischaemic and inflammatory conditions affecting the choroid.
Dr Rupesh Agrawal, is practising as Consultant Ophthalmologist at National Healthcare Group Eye Institute at Tan Tock Seng Hospital, Singapore. After completing his medical studies from Nagpur, India he did his post-graduation and fellowship in Uveitis and Ocular trauma from Sankara Netralaya, Chennai. He was subsequently working as Consultant Ophthalmologist (Uveitis, Ocular Trauma and Cataract) at Shri Ganapati Netralaya, Jalna, India. He also worked briefly at L V Prasad Eye Institute, Hyderabad, India before migrating to Singapore in 2009. Subsequently he is working at Singapore and has been involved in significant translational and basic science research projects. He had very recently completed overseas research training fellowship – awarded by National Medical Research Council Scholarship, Ministry of Health, Singapore at Institute of Ophthalmology, University College London on retinal imaging using retinal leukogram and erythrogram projects and looking at biophysical properties of red blood cells using microfluidics and optical tweezers. He hence looked at mechanical properties of the red blood cell and its implications in microvascular disorders in collaboration with Department of Physics and Astronomy and Department of Mechanical Engineering at UCL, London. He was a visiting scholar at Moorfields Eye Hospital with Prof Carlos Pavesio and accomplished numerous research projects related to ocular tuberculosis and uveitis and currently involved with Moorfields Eye Hospital as Honorary consultant. His areas of interest are Ocular inflammatory disorders including cytokines, ocular tuberculosis and HIV, complex cataract, ocular trauma, ocular nanotechnology, blood corpuscular abnormalities in context of microvascular disorders and retinal imaging. He has published many articles on ocular inflammation in peer reviewed journals and has presented free papers and delivered lectures on ocular trauma and uveitis both nationally and internationally. He is actively involved in numerous collaborative projects on uveitis. He is recipient of many grants for numerous basic science projects pertinent to ocular inflammation. He is currently secretary of International Society of Ocular trauma. He was also conferred with Healthcare Humanity Award by President of Singapore in 2011 for his humanitarian and pro-bono projects in remote areas of the world. He is also serving as Senior Board member of charitable organisation “The Vision Mission” and involved heavily in charity projects across Asia.
1: Agrawal R, Lee CS, Gonzalez-Lopez JJ, Khan S, Rodrigues V, Pavesio C. Flurbiprofen: A Nonselective Cyclooxygenase (COX) Inhibitor for Treatment of Noninfectious, Non-necrotizing Anterior Scleritis. Ocul Immunol Inflamm. 2015 Aug 26:1-8. [Epub ahead of print] PubMed PMID: 26308394.
2: Panwar N, Huang P, Lee J, Keane PA, Chuan TS, Richhariya A, Teoh S, Lim TH, Agrawal R. Fundus Photography in the 21st Century-A Review of Recent Technological Advances and Their Implications for Worldwide Healthcare. Telemed J E Health. 2015 Aug 26. [Epub ahead of print] PubMed PMID: 26308281.
3: Agrawal R, Lavric A, Restori M, Pavesio C, Sagoo MS. NODULAR POSTERIOR SCLERITIS: Clinico-Sonographic Characteristics and Proposed Diagnostic Criteria. Retina. 2015 Aug 19. [Epub ahead of print] PubMed PMID: 26296144.
4: Potter J, Agrawal R, Barraclough C, Rahman F, Westcott M, Pavesio CE, White V. Moxifloxacin: An Alternative to Ethambutol for the Treatment of Presumed Ocular Tuberculosis. Ocul Immunol Inflamm. 2015 Aug 19:1-7. [Epub ahead of print] PubMed PMID: 26222893.
5: Agrawal R, Gonzalez-Lopez JJ, Nobre-Cardoso J, Gupta B, Grant R, Addison PK, Westcott M, Pavesio CE. Predictive factors for treatment failure in patients with presumed ocular tuberculosis in an area of low endemic prevalence. Br J Ophthalmol. 2015 Jul 17. pii: bjophthalmol-2014-306474. doi: 10.1136/bjophthalmol-2014-306474. [Epub ahead of print] PubMed PMID: 26187952.
6: Tan KA, Agrawal R. Luminal and Stromal Areas of Choroid Determined by Binarization Method of Optical Coherence Tomographic Images. Am J Ophthalmol. 2015 Aug;160(2):394. doi: 10.1016/j.ajo.2015.04.039. PubMed PMID: 26187882.
7: Lavric A, Gonzalez-Lopez JJ, Majumder PD, Bansal N, Biswas J, Pavesio C, Agrawal R. Posterior Scleritis: Analysis of Epidemiology, Clinical Factors, and Risk of Recurrence in a Cohort of 114 Patients. Ocul Immunol Inflamm. 2015 Jul 2:1-10. [Epub ahead of print] PubMed PMID: 26134101.
8: Lee C, Agrawal R, Pavesio C. Ocular Tuberculosis-A Clinical Conundrum. Ocul Immunol Inflamm. 2015 Aug 19:1-6. [Epub ahead of print] PubMed PMID: 26110355.
9: Bansal S, Barathi VA, Iwata D, Agrawal R. Experimental autoimmune uveitis and other animal models of uveitis: An update. Indian J Ophthalmol. 2015 Mar;63(3):211-8. doi: 10.4103/0301-4738.156914. PubMed PMID: 25971165; PubMed Central PMCID: PMC4448233.
10: Agrawal R, Gupta B, Gonzalez-Lopez JJ, Rahman F, Phatak S, Triantafyllopoulou I, Addison PK, Westcott M, Pavesio CE. The role of anti-tubercular therapy in patients with presumed ocular tuberculosis. Ocul Immunol Inflamm. 2015 Feb;23(1):40-6. doi: 10.3109/09273948.2014.986584. PubMed PMID: 25615809.
11: Agrawal R, Lee C, Phatak S, Pavesio C. Immunopharmacotherapy of non-infectious uveitis: where do we stand? Expert Opin Biol Ther. 2014 Dec;14(12):1719-22. doi: 10.1517/14712598.2014.963049. Epub 2014 Sep 22. Review. PubMed PMID: 25244075; PubMed Central PMCID: PMC4548880.